57 days in South America Itinerary

57 days in South America Itinerary

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Route & dates

57 days in South America Itinerary

Start: Rome, Italy
Fly:  16​h
1
Belem, Brazil
— 2 nights
Fly:  4​h
2
Manaus, Brazil
— 2 nights
Fly + bus:  9​h 45​min
3
Salvador, Brazil
— 3 nights
Fly:  6​h
4
Rio de Janeiro, Brazil
— 5 nights
Fly:  6​h 45​min
5
Buenos Aires, Argentina
— 5 nights
6
Mendoza, Argentina
— 5 nights
Fly + shuttle:  3​h 15​min
7
Valparaiso, Chile
— 4 nights
bus:  1​h 30​min
8
Santiago, Chile
— 4 nights
Fly:  5​h 45​min
9
Punta Arenas, Chile
— 3 nights
Fly:  7​h 30​min
10
Calama, Chile
— 1 night
Drive:  12​h 30​min
11
Arequipa, Peru
— 2 nights
12
Cusco, Peru
— 4 nights
Fly:  7​h 15​min
13
Medellin, Colombia
— 5 nights
Fly:  4​h
14
Cartagena, Colombia
— 4 nights
Fly:  18​h 30​min
End: Rome, Italy

2
nights
Belem, Brazil

Belem ©
With its roots as the first European colony on the Amazon River, Belem has played an important part in the history of northern Brazil.
Start off your visit on the 5th (Sun): don't miss a visit to Estacao das Docas, then contemplate the long history of Forte do Presepio, then get outside with Praca Batista Campos, and finally take in the architecture and atmosphere at Basilica de Nossa Senhora de Nazare. Keep things going the next day: tour the pleasant surroundings at Parque Estadual do Utinga and then surround yourself with nature on a nature and wildlife tour.

To find photos, where to stay, traveler tips, and tourist information, read Belem trip planner .

Rome, Italy to Belem is an approximately 16-hour flight. You can also do a combination of train and flight. The time zone changes from Central European Time (CET) to Brasilia Time (BRT), which is usually a -4 hour difference. Traveling from Rome in April, you will find days in Belem are somewhat warmer (35°C), and nights are much hotter (27°C). Finish your sightseeing early on the 6th (Mon) so you can travel to Manaus.

Things to do in Belem

Outdoors Tours Wildlife
Find places to stay Apr 4 — 6:
Highlights from your plan
Praca Batista Campos ©
Praca Batista Campos
Basilica de Nossa Senhora de Nazare ©
Forte do Presepio ©
Forte do Presepio

2
nights
Manaus, Brazil

Manaus ©
It's hard not to get excited when planning a trip to Manaus, capital of the state of Amazonas, and the largest city on the mighty Amazon River.
Satisfy your inner culture vulture at Church of Sao Sebastiao e Sao Francisco de Assis and Palacio Rio Negro. Get in touch with nature at Meeting of Waters and Nature & Wildlife Tours. There's still lots to do: enjoy the sand and surf at Ponta Negra Beach, don't miss a visit to Espaco Cultural Largo de Sao Sebastiao, see the interesting displays at Amazonia Museum of Natural Science, and take in panoramic vistas at Museu da Amazonia (MUSA).

To find reviews, photos, maps, and other tourist information, refer to the Manaus online trip planner .

Getting from Belem to Manaus by flight takes about 4 hours. Other options: do a combination of bus and ferry; or ride a ferry. Traveling from Belem to Manaus, you'll gain 1 hour due to the time zone difference. April in Manaus sees daily highs of 35°C and lows of 28°C at night. Wrap up your sightseeing on the 9th (Thu) early enough to travel to Salvador.

Things to do in Manaus

Outdoors Tours Wildlife
Find places to stay Apr 6 — 9:
Highlights from your plan
Ponta Negra Beach ©
Ponta Negra Beach
Meeting of Waters ©
Meeting of Waters
Nature & Wildlife Tours

3
nights
Salvador, Brazil

Salvador ©
Nowhere are the traditions of Brazil's African-background community as strong as in Salvador, the colorful, historical capital of Bahia state.
Pelourinho and Casa do Rio Vermelho are good opportunities to explore the local culture. Your inner history buff will appreciate Igreja de Nosso Senhor do Bonfim and Our Lady of Ajuda Church. Step out of Salvador to go to Guarajuba and see Guarajuba Beach, which is approximately 1h 55 min away. There's much more to do: tour the pleasant surroundings at Praia Farol da Barra, appreciate the history behind Elevator Lacerda, contemplate in the serene atmosphere at Sao Francisco Church and Convent, and kick back and relax at Praia do Porto da Barra.

To see ratings, more things to do, other places to visit, and tourist information, read our Salvador planner .

You can do a combination of flight and bus from Manaus to Salvador in 10 hours. Another option is to take a bus. You'll lose 1 hour traveling from Manaus to Salvador due to the time zone difference. In April, plan for daily highs up to 34°C, and evening lows to 28°C. Finish your sightseeing early on the 13th (Mon) so you can travel to Rio de Janeiro.

Things to do in Salvador

Beaches Parks Outdoors

Side Trip

Guarajuba Beach
Find places to stay Apr 9 — 13:
Highlights from your plan
Praia Farol da Barra ©
Praia Farol da Barra
Igreja de Nosso Senhor do Bonfim ©
Igreja de Nosso Senhor do Bonfim
Pelourinho ©
Pelourinho

5
nights
Rio de Janeiro, Brazil

Rio de Janeiro ©
Bustling with samba music and all-night street parties, no city encapsulates the spirit of Brazil better than Rio de Janeiro.
Deepen your sense of the past at sights like Parque Lage and The Metropolitan Cathedral of Saint Sebastian. Satisfy your inner culture vulture at Praia de Ipanema and Sugarloaf Mountain. The adventure continues: enjoy the sand and surf at Copacabana Beach, get great views at Leblon Beach, stroll through Pedra do Arpoador, and admire the masterpieces at Centro Cultural Banco do Brasil - CCBB Rio de Janeiro.

To see where to stay, photos, maps, and tourist information, go to the Rio de Janeiro online attractions planner .

You can fly from Salvador to Rio de Janeiro in 6 hours. Alternatively, you can drive; or take a bus. In April, daytime highs in Rio de Janeiro are 33°C, while nighttime lows are 26°C. Cap off your sightseeing on the 19th (Sun) early enough to travel to Buenos Aires.

Things to do in Rio de Janeiro

Parks Nature Beaches
Find places to stay Apr 13 — 19:
Highlights from your plan
Copacabana Beach ©
Copacabana Beach
Praia de Ipanema
Praia de Ipanema
Pao de Acucar ©
Pao de Acucar

5
nights
Buenos Aires, Argentina

Buenos Aires ©
Cultural capital of South America, Buenos Aires remains one of the largest cities on the continent, serving as a point of departure for exploring the rest of the country.
Parque 3 de Febrero and San Telmo are good opportunities to explore the local culture. Deepen your sense of the past at sights like Plaza de Mayo and Catedral Metropolitana. Next up on the itinerary: don't miss a visit to Recoleta Cemetery, admire the masterpieces at Museo Nacional de Bellas Artes, wander the streets of Recoleta, and get a sense of history and politics at Casa Rosada.

To find traveler tips, photos, where to stay, and tourist information, refer to the Buenos Aires trip itinerary planner.

Traveling by flight from Rio de Janeiro to Buenos Aires takes 7 hours. Alternatively, you can drive; or take a bus. Traveling from Rio de Janeiro in April, things will get a bit cooler in Buenos Aires: highs are around 26°C and lows about 19°C. Finish up your sightseeing early on the 24th (Fri) so you can travel to Mendoza.

Things to do in Buenos Aires

Historic Sites Neighborhoods Shopping
Find places to stay Apr 19 — 24:
Highlights from your plan
Puerto Madero ©
Puerto Madero
Parque 3 de Febrero ©
Parque 3 de Febrero
Plaza de Mayo ©
Plaza de Mayo

5
nights
Mendoza, Argentina

Mendoza ©
Famed for its neat vineyards and thriving wine production, Mendoza remains the place to visit for a pleasant combination of relaxation and recreation.
Do some cultural sightseeing at Bodega Matervini and Bodega Roberto Bonfanti. Santuario Virgen de Lourdes and Plaza Espana will appeal to history buffs. Explore the numerous day-trip ideas around Mendoza: Bodegas Salentein (in Los Arboles) and Casa El Enemigo (in Maipu). And it doesn't end there: learn about winemaking at Bodega Cruzat. Bubbles Experience, explore the striking landscape at Canon del Atuel, stroll around Parque General San Martin, and take an in-depth tour of Museo Fundacional.

To see more things to do, ratings, traveler tips, and tourist information, you can read our Mendoza travel route builder site .

Getting from Buenos Aires to Mendoza by flight takes about 3.5 hours. Other options: drive; or take a bus. Traveling from Buenos Aires in April, plan for little chillier nights in Mendoza, with lows around 13°C. Cap off your sightseeing on the 29th (Wed) early enough to travel to Valparaiso.

Things to do in Mendoza

Wineries Parks Historic Sites

Side Trips

Casa El Enemigo, Bodegas Salentein, Santuario Virgen de Lourdes, Canon del Atuel
Find places to stay Apr 24 — 29:
Highlights from your plan
Bodega Tierras Altas ©
Bodega Tierras Altas
Bodega Matervini ©
Bodega Matervini
Bodega Roberto Bonfanti ©
Bodega Roberto Bonfanti

4
nights
Valparaiso, Chile

Valparaiso ©
Navigating through a maze of colorful streets winding up and down steep hills remains an integral part of any Valparaiso tour.
Escape the urban bustle at Reñaca and Mirador Diego Portales. Get a sense of the local culture at La Sebastiana and Lutheran Church of the Holy Cross (1897). The adventure continues: take in the local highlights with Walking tours, get to know the fascinating history of Paseo 21 de Mayo, take some stellar pictures from Paseo Yugoslavo, and step into the grandiose world of Palacio Polanco.

To see reviews, maps, and more tourist information, use the Valparaiso trip website .

You can do a combination of flight and shuttle from Mendoza to Valparaiso in 3.5 hours. Alternatively, you can drive; or take a bus. The time zone difference when traveling from Mendoza to Valparaiso is minus 1 hour. When traveling from Mendoza in April, plan for little chillier days in Valparaiso, with highs around 22°C, while nights are about the same with lows around 13°C. Cap off your sightseeing on the 3rd (Sun) early enough to catcht the bus to Santiago.

Things to do in Valparaiso

Historic Sites Outdoors Museums

Side Trip

Vina del Mar
Find places to stay Apr 29 — May 3:
Highlights from your plan
Paseo Gervasoni ©
Paseo Gervasoni
La Sebastiana ©
La Sebastiana
Reñaca ©
Reñaca

4
nights
Santiago, Chile

Santiago ©
Santiago tourism thrives largely thanks to the city's big selection of cultural and entertainment options, including museums, theaters, restaurants, bars, and giant malls.
Get a sense of the local culture at La Chascona and Museo de la Memoria y los Derechos Humanos. Visit Centro Cultural Palacio de la Moneda y Plaza de la Ciudadania and Former National Congress Building for their historical value. Step out of Santiago to go to Pirque and see Concha y Toro, which is approximately 38 minutes away. There's much more to do: take some stellar pictures from San Cristóbal Hill, wander the streets of Barrio Lastarria, contemplate in the serene atmosphere at Iglesia de La Merced, and make a trip to Santa Lucia Hill.

To see where to stay, more things to do, and tourist information, refer to the Santiago vacation planning website .

Traveling by bus from Valparaiso to Santiago takes 1.5 hours. Alternatively, you can drive. Finish your sightseeing early on the 8th (Fri) to allow enough time to travel to Punta Arenas.

Things to do in Santiago

Museums Historic Sites Neighborhoods

Side Trip

Concha y Toro
Find places to stay May 3 — 8:
Highlights from your plan
La Chascona ©
La Chascona
San Cristóbal Hill ©
San Cristóbal Hill
Museo Chileno de Arte Precolombino ©

3
nights
Punta Arenas, Chile

An erstwhile hub of the sheep wool industry, Punta Arenas has evolved into a gateway of sorts for hikers, cruise ship passengers, and adventure travelers heading out on the windswept lands of Chile's extreme southern reaches.
Escape the urban bustle at Dolphin & Whale Watching and Strait of Magellan. Popular historic sites such as Cementerio Municipal and Parque Del Estrecho De Magallanes are in your itinerary. There's lots more to do: examine the collection at Palacio Sara Braun, brush up on your military savvy at Museo Naval y Maritimo, get engrossed in the history at Museo Regional De Magallanes, and ponder the world of politics at Palacio Montes Pello.

For other places to visit, reviews, where to stay, and more tourist information, read our Punta Arenas online tour planner .

Getting from Santiago to Punta Arenas by flight takes about 6 hours. Other options: drive; or take a bus. May in Punta Arenas sees daily highs of 7°C and lows of 1°C at night. Finish your sightseeing early on the 12th (Tue) so you can travel to Calama.

Things to do in Punta Arenas

Outdoors Historic Sites Tours
Find places to stay May 8 — 12:
Highlights from your plan
Dolphin & Whale Watching
Cementerio Municipal ©
Cementerio Municipal
Palacio Sara Braun ©
Palacio Sara Braun

1
night
Calama, Chile

Calama ©
A hub of northern Chile's copper mining industry, Calama acts as a gateway for exploration of the geological and archaeological sites in the Atacama desert region.
Kick off your visit on the 12th (Tue): take in the architecture and atmosphere at Iglesia de San Francisco de Chiu Chiu, then get outside with Sol Del Desierto, and then make a trip to Mina de Chuquicamata.

For maps, traveler tips, ratings, and other tourist information, read Calama trip itinerary maker app .

You can fly from Punta Arenas to Calama in 7.5 hours. Alternatively, you can drive; or take a bus. When traveling from Punta Arenas in May, plan for warmer days in Calama, with highs around 25°C, while nights are about the same with lows around 2°C. Wrap up your sightseeing by early afternoon on the 13th (Wed) to allow time for travel to Arequipa.

Things to do in Calama

Outdoors Shopping Historic Sites

Side Trip

Iglesia de San Francisco de Chiu Chiu
Find places to stay May 12 — 13:
Highlights from your plan
Sol Del Desierto ©
Sol Del Desierto
Iglesia de San Francisco de Chiu Chiu ©
Mina de Chuquicamata ©
Mina de Chuquicamata

2
nights
Arequipa, Peru

Arequipa ©
In an area dominated three imposing volcanoes, Arequipa vacations allow visitors to admire well-preserved colonial architecture in a dramatic setting.
Start off your visit on the 14th (Thu): examine the collection at Santa Catalina Monastery, get engrossed in the history at Museo Santuarios Andinos, then see the interesting displays at Cathedral of Arequipa Museum, then steep yourself in history at Historic Centre of Arequipa, and finally enjoy breathtaking views from Yanahuara. Get ready for a full day of sightseeing on the next day: examine the collection at MUVI Museo Vivencial del Vino y Pisco, get impressive views of Volcan Misti, and then stop by Alpaca AB.

For traveler tips, more things to do, reviews, and other tourist information, read our Arequipa tour itinerary builder .

Getting from Calama to Arequipa by car takes about 13 hours. Other options: fly. You'll gain 1 hour traveling from Calama to Arequipa due to the time zone difference. Traveling from Calama in May, plan for somewhat warmer nights in Arequipa, with lows around 10°C. Wrap up your sightseeing on the 15th (Fri) to allow time to travel to Cusco.

Things to do in Arequipa

Museums Historic Sites Nature
Find places to stay May 13 — 15:
Highlights from your plan
Santa Catalina Monastery ©
Santa Catalina Monastery
Historic Centre of Arequipa ©
Historic Centre of Arequipa
Museo Santuarios Andinos ©
Museo Santuarios Andinos

4
nights
Cusco, Peru

Cusco ©
Capital of the Inca Empire for three centuries, World Heritage-listed Cusco is now a major tourist destination, drawing nearly 2 million annual tourists with its well-preserved colonial architecture and proximity to Machu Picchu.
Your inner history buff will appreciate Sacsayhuaman and Plaza de Armas. Satisfy your inner culture vulture at Centro Historico De Cusco and Iglesia De Santo Domingo. Change things up with these side-trips from Cusco: Maras (Salinas de Maras & Moray) and Centro Texti Urpi (in Chinchero). The adventure continues: explore the ancient world of Sacred Valley of the Incas, take an in-depth tour of Museo de Vida Monastica - Monasterio de Santa Catalina del Cusco, see the interesting displays at Museo Quechua, and admire the masterpieces at Museo de Arte Precolombino.

For more things to do, photos, traveler tips, and more tourist information, refer to the Cusco day trip planner.

You can fly from Arequipa to Cusco in 1.5 hours. Other options are to drive; or take a bus. Traveling from Arequipa in May, plan for a bit cooler nights in Cusco, with lows around 4°C. Finish up your sightseeing early on the 20th (Wed) so you can travel to Medellin.

Things to do in Cusco

Historic Sites Museums Parks

Side Trips

Maras, Centro Texti Urpi, Sacred Valley of the Incas
Find places to stay May 15 — 20:
Highlights from your plan
Sacsayhuaman ©
Sacsayhuaman
Centro Historico De Cusco ©
Centro Historico De Cusco
Plaza de Armas ©
Plaza de Armas

5
nights
Medellin, Colombia

Medellin ©
Nestled between rising hills in a narrow valley, Medellin serves as an energetic melting pot of people from all socio-economic classes.
Popular historic sites such as Templo Parroquial Jesus Nazareno and Metropolitan Cathedral Basilica are in your itinerary. Get in touch with nature at 2000m Descent and more and Parque Arvi. Explore the numerous day-trip ideas around Medellin: Parque Tematico Replica del Viejo Penol (in Penol) and Piedra Del Penol (in Guatape). The adventure continues: take in the local highlights with Walking tours, steep yourself in history at Pueblito Paisa, admire nature's wide array of creatures at Parque Explora, and get engrossed in the history at Museo de Antioquia.

To find ratings, other places to visit, traveler tips, and tourist information, you can read our Medellin road trip planner.

Fly from Cusco to Medellin in 7.5 hours. Alternatively, you can drive; or take a bus. Expect somewhat warmer weather when traveling from Cusco in May: highs in Medellin hover around 32°C, while lows dip to 20°C. Finish up your sightseeing early on the 25th (Mon) so you can travel to Cartagena.

Things to do in Medellin

Parks Tours Outdoors

Side Trips

Piedra Del Penol, Parque Tematico Replica del Viejo Penol
Find places to stay May 20 — 25:
Highlights from your plan
Piedra Del Penol ©
Piedra Del Penol
Parque Arvi ©
Parque Arvi
Parasailing & Paragliding

4
nights
Cartagena, Colombia

Cartagena ©
The site of the continent's first Spanish colony, Cartagena retains much of its colonial flavor thanks to a World Heritage-listed old town, encircled by old walls and protected by imposing fortresses.
Get outdoors at Playa Blanca and Scuba & Snorkeling. Deepen your sense of the past at sights like Castillo San Felipe de Barajas and Convent of Santa Cruz de la Popa. There's much more to do: contemplate the long history of Walled City of Cartagena, make a trip to Torre del Reloj, pause for some serene contemplation at Sanctuary of Saint Peter Claver, and see the interesting displays at Caribe Jewelry and Emerald Museum.

For maps, reviews, more things to do, and tourist information, go to the Cartagena trip itinerary planning app .

Getting from Medellin to Cartagena by flight takes about 4 hours. Other options: do a combination of flight and bus; or drive. Traveling from Medellin in May, things will get a bit warmer in Cartagena: highs are around 38°C and lows about 30°C. On the 29th (Fri), wrap the sightseeing up by early afternoon so you can travel back home.

Things to do in Cartagena

Outdoors Tours Historic Sites

Side Trip

Playa Blanca
Find places to stay May 25 — 29:
Highlights from your plan
Walled City of Cartagena ©
Walled City of Cartagena
Castillo de San Felipe de Barajas ©
Castillo de San Felipe de Barajas
Plaza Santo Domingo ©
Plaza Santo Domingo

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