22 days in South America Itinerary

22 days in South America Itinerary

Created using Inspirock South America trip planner
Make it your trip
+2
Fly to Baltra Island, Ferry to Santa Cruz Ferry Terminal, Bus to Puerto Ayora
1
Puerto Ayora, Ecuador
— 3 nights
+2
Bus to Santa Cruz Ferry Terminal, Ferry to Isla Baltra Ferry Terminal, Fly to Buenos Aires
2
Buenos Aires, Argentina
— 2 nights
Fly
3
El Calafate, Argentina
— 1 night
Bus
4
El Chalten, Argentina
— 3 nights
Bus to El Calafate, Fly to San Carlos de Bariloche
5
San Carlos de Bariloche, Argentina
— 3 nights
Bus to Osorno, Fly to San Pedro de Atacama
6
San Pedro de Atacama, Chile
— 2 nights
Fly
7
Cusco, Peru
— 5 nights
Fly

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Puerto Ayora, Ecuador — 3 nights

The largest settlement in the Galapagos, Puerto Ayora offers visitors to the islands an array of facilities and things to do.
Start off your visit on the 2nd (Sun): race across the water with a speed boat tour and then tour the pleasant surroundings at Charles Darwin Research Station. Here are some ideas for day two: take in the exciting artwork at Samay Latin Art, explore the striking landscape at Las Grietas, and then explore the activities along Laguna las Ninfas.

To see maps, photos, traveler tips, and other tourist information, you can read our Puerto Ayora trip itinerary maker app.

Guadalajara, Mexico to Puerto Ayora is an approximately 19.5-hour combination of flight, ferry, and bus. Traveling from Guadalajara to Puerto Ayora, you'll lose 1 hour due to the time zone difference. Traveling from Guadalajara in October, expect somewhat warmer with lows of 24°C in Puerto Ayora. Finish your sightseeing early on the 4th (Tue) to allow enough time to travel to Buenos Aires.
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Parks · Wildlife · Nature · Outdoors
Find places to stay Oct 1 — 4:

Buenos Aires, Argentina — 2 nights

Cultural capital of South America, Buenos Aires remains one of the largest cities on the continent, serving as a point of departure for exploring the rest of the country.
Kick off your visit on the 5th (Wed): surround yourself with nature on a nature and wildlife tour. Get ready for a full day of sightseeing on the next day: pause for some serene contemplation at Catedral de San Isidro, explore the historical opulence of Palacio de Aguas Corrientes, then make a trip to Cemiterio de Recoleta, and finally steep yourself in history at Palacio Barolo.

To find reviews, maps, and tourist information, go to the Buenos Aires holiday planner.

Traveling by combination of bus, ferry, and flight from Puerto Ayora to Buenos Aires takes 18 hours. Alternatively, you can do a combination of ferry and flight. Due to the time zone difference, you'll lose 2 hours traveling from Puerto Ayora to Buenos Aires. Traveling from Puerto Ayora in October, things will get a bit cooler in Buenos Aires: highs are around 24°C and lows about 17°C. Wrap up your sightseeing on the 7th (Fri) early enough to fly to El Calafate.
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Side Trip
Find places to stay Oct 4 — 7:

El Calafate, Argentina — 1 night

El Calafate tourism thrives mostly thanks to the city's proximity to a World Heritage-listed national park, famed for containing over 40 large glaciers.
On the 7th (Fri), catch some excitement at Estancia 25 de Mayo, then examine the collection at El Calafate Historical Interpretation Center, and then head outdoors with Enjoy!.

To find traveler tips, maps, and tourist information, you can read our El Calafate trip itinerary planning site.

You can fly from Buenos Aires to El Calafate in 5 hours. Alternatively, you can drive; or take a bus. When traveling from Buenos Aires in October, plan for colder days in El Calafate, with highs around 9°C, while nights are a bit cooler with lows around 8°C. Wrap up your sightseeing on the 8th (Sat) early enough to take a bus to El Chalten.
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Wildlife · Outdoors · Fun & Games · Parks
Find places to stay Oct 7 — 8:

El Chalten, Argentina — 3 nights

Nestled up against the hills of the Los Glaciares National Park, El Chalten serves as one of the nation's most bustling hubs for hikers and backpackers heading out into the wild landscape of southern Patagonia.
Escape the urban bustle at Laguna de los Tres and Glaciar Piedras Blancas. Discover out-of-the-way places like Amanecer en El Chalten and Casa Madsen Museo. There's much more to do: head outdoors with Mirador Rio De Las Vueltas, take your sightseeing to a higher altitude at Sendero Loma del Pliegue Tumbado, and surround yourself with nature on Mountaineering Patagonia.

To find maps, more things to do, reviews, and other tourist information, read El Chalten trip builder website.

Traveling by bus from El Calafate to El Chalten takes 3.5 hours. Alternatively, you can drive; or take a shuttle. Wrap up your sightseeing on the 11th (Tue) to allow time to travel to San Carlos de Bariloche.
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Parks · Outdoors · Nature · Wildlife
Side Trip
Find places to stay Oct 8 — 11:

San Carlos de Bariloche, Argentina — 3 nights

Nestled against the foothills of the Andes, scenic San Carlos de Bariloche hugs the southern shore of Nahuel Huapi Lake and ranks among Argentina's top destinations for active outdoor vacations.
Get in touch with nature at Kayaking & Canoeing and Circuito Chico. Step off the beaten path and head to Parroquia San Eduardo and Evo Sports. There's still lots to do: explore the striking landscape of Parque Nacional Nahuel Huapi, let your taste buds guide you at a local gastronomic tour, explore the engaging exhibits at Museo Paleontologico Bariloche, and head outdoors with Circuito Grande.

To find maps, where to stay, more things to do, and tourist information, you can read our San Carlos de Bariloche day trip planning site.

Traveling by combination of bus and flight from El Chalten to San Carlos de Bariloche takes 7 hours. Alternatively, you can take a bus; or drive. October in San Carlos de Bariloche sees daily highs of 17°C and lows of 1°C at night. Wrap up your sightseeing by early afternoon on the 14th (Fri) to allow time for travel to San Pedro de Atacama.
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Parks · Outdoors · Wildlife · Nature
Find places to stay Oct 11 — 14:

San Pedro de Atacama, Chile — 2 nights

Major archeological sites and a renowned museum remain the big draws in San Pedro de Atacama tourism, appealing to visitors interested in learning more about South America's pre-Columbian cultures.
Kick off your visit on the 15th (Sat): explore the activities along Quebrada del Diablo and then explore the ancient world of Pukara de Quitor. Keep things going the next day: see exotic creatures in open habitats at On Safari Atacama and then enjoy unforgettable views with a balloon tour.

Make your San Pedro de Atacama itinerary with Inspirock to find out what to see and where to go.

You can do a combination of bus and flight from San Carlos de Bariloche to San Pedro de Atacama in 12 hours. Alternatively, you can do a combination of bus and flight; or drive. The time zone changes from Argentina Standard Time to Chile Standard Time, which is usually a -1 hour difference. Traveling from San Carlos de Bariloche in October, you will find days in San Pedro de Atacama are somewhat warmer (28°C), and nights are about the same (3°C). Wrap up your sightseeing on the 17th (Mon) early enough to fly to Cusco.
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Outdoors · Tours · Wildlife · Parks
Find places to stay Oct 14 — 17:

Cusco, Peru — 5 nights

Capital of the Inca Empire for three centuries, World Heritage-listed Cusco is now a major tourist destination, drawing nearly 2 million annual tourists with its well-preserved colonial architecture and proximity to Machu Picchu.
Your inner history buff will appreciate Sacsayhuaman and Iglesia de la Compania de Jesus. Discover out-of-the-way places like Q'enqo and Tierras Vivas. And it doesn't end there: gain a rich perspective with exploor, pause for some serene contemplation at Iglesia San Pedro, contemplate the long history of Qorikancha, and paddle through the water with a kayaking and canoeing tour.

For ratings, maps, and other tourist information, read our Cusco online tour itinerary planner.

You can fly from San Pedro de Atacama to Cusco in 9 hours. Alternatively, you can drive; or take a bus. Traveling from San Pedro de Atacama to Cusco, you'll gain 1 hour due to the time zone difference. When traveling from San Pedro de Atacama in October, plan for little chillier days and about the same nights in Cusco: temperatures range from 24°C by day to 7°C at night. Wrap up your sightseeing on the 22nd (Sat) to allow time to fly back home.
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Historic Sites · Outdoors · Tours · Parks
Find places to stay Oct 17 — 22:

Ecuador travel guide

4.5
With abundant opportunities to discover fascinating World Heritage Sites, a holiday in Ecuador remains among the most culturally enriching travel experiences. Home to the world's highest active volcano, this little country packs a big punch when it comes to tourist activities. Some of the most popular things to do in Ecuador include visits to its astonishingly biodiverse wilderness areas, home to some 1,500 bird species, 840 species of amphibians and reptiles, and nearly 20,000 plant species. Of course, the highlight of many Ecuador vacations is bound to be the Galapagos Islands, made famous by naturalist Charles Darwin. Aside from the stunning nature, Ecuador also boasts many historic cities filled with photogenic colonial-era churches, mansions, and plazas.
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Argentina travel guide

4.3
Landmarks · Bodies of Water · Specialty Museums
Land of Contrasts
Home to the highest and lowest points in South America, diverse Argentina enthralls visitors with its contrasting landscapes and rich cultural heritage. A tour of Argentina reveals a sprawling land of fiercely proud and hardworking gauchos, the legendary cowboys of South America's pampas. A vacation in Argentina also leads you to giant urban centers, filled with modern tourist attractions that include fine restaurants, award-winning museums, and renowned public parks, gardens, and zoos. Away from big cities, Argentina sightseeing combines visits to mighty waterfalls situated inside World Heritage-listed national parks in the north of the country, with excursions to icy glaciers in the south.
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Chile travel guide

4.3
Landmarks · Parks · Specialty Museums
Land of Poets
Squeezed between the Andes and the Pacific Ocean, geographically diverse Chile is a long, thin stretch of land encompassing some of the world's driest deserts in the north, and some of its largest glacial fields in the south. Though most Chile holidays include some form of adventure in the vast wilderness areas, the country also contains charming cities providing plenty of urban things to do and see. Many tours of Chile include at least a brief visit to the country's lush wine regions, where backyard vineyards compete with sprawling estates producing some of the world's most respected whites and reds.
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Peru travel guide

4.6
Historic Sites · Parks · Landmarks
Land of the Incas
In a country renowned for its pre-Columbian archeological sites, no Peru vacation would be complete without an adrenaline-inducing hike to Machu Picchu, World Heritage-listed symbol of the once-mighty Incan Empire. Aside from visiting these spectacular ruins set against the backdrop of photogenic mountain peaks, most holidays in Peru also include an exploration of the country's pretty cities, boasting well-preserved colonial architecture and a slew of modern buildings housing fine museums, galleries, shops, and restaurants. Ideal for active vacationers, Peru trips are also tailor-made for gourmands, as the country's eclectic cuisine blends tasty influences from Africa, Asia, and Europe.
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