22 days in Europe Itinerary

Barcelona, the country’s second-largest city, is a cosmopolitan urban center known for its throbbing youthful energy and stellar architecture.

Kick off your visit on the 9th (Sat): stroll through Park Guell, admire the landmark architecture of Basilica of the Sagrada Familia, and then pause for some photo ops at Casa Mila - La Pedrera. On your second day here, pause for some photo ops at Casa Batllo, take a stroll through El Barri Gòtic, and then take in the architecture and atmosphere at Barcelona Cathedral.

For maps, more things to do, where to stay, and tourist information, read Barcelona travel route builder app .

San Francisco, USA to Barcelona is an approximately 14.5-hour combination of subway and flight. You can also fly; or do a combination of flight and train. The time zone difference moving from Pacific Standard Time to Central European Time is 9 hours. March in Barcelona sees daily highs of 62°F and lows of 47°F at night. Finish up your sightseeing early on the 10th (Sun) so you can travel to Rome.

Aptly nicknamed the Eternal City, Rome is the birthplace of the Roman Empire, one of the world's greatest civilizations ever.

Vatican Museums and Galleria Borghese will appeal to museum buffs. Popular historic sites such as Colosseum and Roman Forum are in your itinerary. And it doesn't end there: explore the ancient world of Palatine Hill, admire the landmark architecture of Pantheon, make a trip to St. Peter's Basilica, and get to know the fascinating history of Piazza Navona.

For photos, ratings, maps, and more tourist information, read our Rome route app .

You can fly from Barcelona to Rome in 5 hours. Other options are to drive; or take a train. In March, daily temperatures in Rome can reach 61°F, while at night they dip to 45°F. Wrap up your sightseeing on the 13th (Wed) to allow time to take a train to Florence.

Considered a cultural, artistic, and architectural jewel of Italy, Florence is the birthplace of the Italian Renaissance.

Eschew the tourist crowds and head to Siena Cathedral and Piazza del Campo. Your inner history buff will appreciate Cathedral of Santa Maria del Fiore and Piazza del Duomo. And it doesn't end there: explore the world behind art at Uffizi Galleries, take in panoramic vistas at Campanile di Giotto, don't miss a visit to Piazzale Michelangelo, and examine the collection at Galleria dell'Accademia.

To see photos, more things to do, and other tourist information, read our Florence trip site .

You can take a train from Rome to Florence in 1.5 hours. Other options are to drive; or fly. Expect a daytime high around 59°F in March, and nighttime lows around 42°F. Finish up your sightseeing early on the 16th (Sat) so you can catch the train to Venice.

Virtually unchanged for the last six centuries, Venice is actually a group of islands made famous by a series of canals, bridges, monuments, piazzas, and narrow pedestrian lanes.

Discover out-of-the-way places like San Giorgio Maggiore and St Mark's Campanile. Museum-lovers will get to explore Doge's Palace and Gallerie dell'Accademia. When in Venice, make a side trip to see Scrovegni Chapel in Padua, approximately 52 minutes away. The adventure continues: make a trip to Basilica di San Marco, contemplate the waterfront views at Canal Grande, get to know the fascinating history of St. Mark's Square, and take in the views from Ponte di Rialto.

To see where to stay, more things to do, ratings, and other tourist information, refer to the Venice online driving holiday planner .

Traveling by train from Florence to Venice takes 2.5 hours. Alternatively, you can drive; or take a bus. In March, plan for daily highs up to 58°F, and evening lows to 41°F. Finish your sightseeing early on the 19th (Tue) so you can travel to Istanbul.

A physical and cultural bridge between Europe and Asia, the transcontinental city of Istanbul serves as a living reminder of the Roman, Byzantine, and Ottoman empires.

Popular historic sites such as Hagia Sophia Museum / Church (Ayasofya) and Galata Tower are in your itinerary. Do some cultural sightseeing at Kariye Museum (The Chora Church) and Istanbul Modern Museum. And it doesn't end there: get engrossed in the history at Topkapi Palace, steep yourself in history at Historic Areas of Istanbul, admire the striking features of Basilica Cistern, and contemplate in the serene atmosphere at Rustem Pasha Mosque.

For maps, where to stay, traveler tips, and tourist information, read our Istanbul visit planner .

Getting from Venice to Istanbul by flight takes about 5.5 hours. Other options: do a combination of train and flight; or drive. The time zone difference moving from Central European Time to Eastern European Time is 2 hours. Traveling from Venice in March, you can expect nighttime temperatures to be a bit warmer in Istanbul, with lows of 54°F. Cap off your sightseeing on the 22nd (Fri) early enough to travel to Budapest.

You might consider the city of Budapest, divided by the Danube River into two distinctive cities--Buda and Pest--to be essentially one large World Heritage Site.

You'll explore and learn at House of Terror Museum and Hungarian National Gallery (Magyar Nemzeti Galeria). Deepen your sense of the past at sights like Fisherman's Bastion and Matthias Church. Next up on the itinerary: take in the spiritual surroundings of St. Stephen's Basilica (Szent Istvan Bazilika), get to know the fascinating history of Castle Hill, pause for some photo ops at Shoes on the Danube Bank, and steep yourself in history at Liberty Statue.

To find more things to do, maps, reviews, and other tourist information, you can read our Budapest online itinerary builder .

Fly from Istanbul to Budapest in 6 hours. Alternatively, you can do a combination of shuttle and flight; or drive. The time zone difference when traveling from Istanbul to Budapest is minus 2 hours. Expect much colder evenings in Budapest when traveling from Istanbul in March, with lows around 34°F. Cap off your sightseeing on the 25th (Mon) early enough to travel to Prague.

Prague lures millions of tourists each year with its World Heritage-listed medieval city center--a labyrinth of narrow lanes, bridges, cathedrals, and palaces overlooked by a thousand-year-old castle.

Start off your visit on the 26th (Tue): step into the grandiose world of Prague Castle, take in the spiritual surroundings of St. Vitus Cathedral, and then don't miss a visit to Old Town Square. Get ready for a full day of sightseeing on the 27th (Wed): get great views at Vyšehrad National Cultural Monument, get great views at Prague Astronomical Clock, contemplate in the serene atmosphere at Spanish Synagogue, then take an in-depth tour of Jewish Museum in Prague, and finally take in the views from Charles Bridge.

To find other places to visit, traveler tips, more things to do, and other tourist information, you can read our Prague trip planner .

You can fly from Budapest to Prague in 4.5 hours. Alternatively, you can drive; or take a bus. While traveling from Budapest, expect a bit cooler days and about the same nights in Prague, ranging from highs of 49°F to lows of 34°F. Wrap up your sightseeing on the 27th (Wed) to allow time to travel to Amsterdam.

Known as one of the greatest small cities in the world, Amsterdam charms visitors with its cool and cozy atmosphere.

On the 28th (Thu), take an in-depth tour of Anne Frank House, wander the streets of The Jordaan, and then admire the masterpieces at Van Gogh Museum. Keep things going the next day: contemplate the long history of Begijnhof, then explore the world behind art at Rijksmuseum, then get engrossed in the history at The Resistance Museum (Amsterdams Verzetsmuseum), and finally explore the world behind art at Museum Het Rembrandthuis (Rembrandt House).

For more things to do, traveler tips, other places to visit, and tourist information, use the Amsterdam vacation planner.

Getting from Prague to Amsterdam by flight takes about 4.5 hours. Other options: do a combination of flight and train; or drive. In March, daily temperatures in Amsterdam can reach 49°F, while at night they dip to 35°F. Finish your sightseeing early on the 29th (Fri) so you can travel back home.