12 days in Panama City, Quito & Guayaquil Itinerary

12 days in Panama City, Quito & Guayaquil Itinerary

Created using Inspirock trip itinerary builder

Make it your trip
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Panama City, Panama
— 3 nights
Fly
2
Quito, Ecuador
— 4 nights
Fly
3
Guayaquil, Ecuador
— 4 nights

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Panama City, Panama

— 3 nights

Dubai of Latin America

Arguably the most modern of Central American cities, Panama City boasts a shimmering skyline of glass skyscrapers.
Your day by day itinerary now includes Weil Art Gallery, Palacio Bolivar, Independence Square, and other attractions you added. Eschew the tourist crowds and head to Iglesia de la Merced and El Arco Chato. Get some cultural insight at Iglesia de San Francisco de Asis and Museo del Canal Interoceanico de Panama.

To find other places to visit, reviews, and more tourist information, read Panama City trip planner.

If you are flying in from United States, the closest major aiports are Marcos A. Gelabert International Airport, Panamá Pacífico International Airport and Tocumen International Airport. Expect a daytime high around 86°F in November, and nighttime lows around 76°F. You'll have a few hours on the 14th (Sat) to wrap things up before traveling to Quito.

Things to do in Panama City

Find places to stay Nov 11 — 14:

Quito, Ecuador

— 4 nights

Light of America

High in the Andean foothills, Quito remains one of the world's most photogenic capital cities, featuring two dramatic mountain ranges as its backdrop.
You've added Jardin Botanico de Quito, Ridal Galeria Cafe, Ecuador Hop, and other attractions to your itinerary. Explore hidden gems such as Santo Domingo Church and El Sagrario. Your cultural itinerary includes sights like Catedral Metropolitana de Quito and Museum of Maria Augusta Urrutia (La Casa Museo Maria Augusta Urrutia). Next up on the itinerary: get to know the fascinating history of Quito Old Town, take in the spiritual surroundings of Iglesia Santa Barbara, examine the collection at Museo Manuela Saenz, and brush up on your military savvy at Museo Casa de Sucre.

For photos, more things to do, where to stay, and tourist information, go to the Quito visit planner.

You can fly from Panama City to Quito in 6 hours. Expect slightly colder temperatures when traveling from Panama City in November; daily highs in Quito reach 72°F and lows reach 57°F. Finish up your sightseeing early on the 18th (Wed) so you can travel to Guayaquil.

Things to do in Quito

Historic Sites · Tours · Museums · Parks
Find places to stay Nov 14 — 18:

Guayaquil, Ecuador

— 4 nights

Pearl of the Pacific

Hills dotted with colorful houses and waterfront promenades typify Guayaquil, Ecuador's largest city and commercial center.
You've added Iglesia San Jacinto del Morro, Cerro Santa Ana, Catedral Metropolitana de Guayaquil, and other attractions to your itinerary. Get a sense of the local culture at El Faro de Guayaquil and Cementerio Patrimonial de Guayaquil. Deepen your sense of the past at sights like Schoenstatt Sanctuary and Iglesia de La Merced.

To see reviews, traveler tips, and tourist information, you can read our Guayaquil trip planner.

You can fly from Quito to Guayaquil in 3 hours. Other options are to drive; or take a bus. Traveling from Quito in November, expect Guayaquil to be somewhat warmer, temps between 87°F and 71°F.

Things to do in Guayaquil

Historic Sites · Parks · Neighborhoods · Wildlife
Find places to stay Nov 18 — 22: